Palmitoyl tripeptide-5 (Palmitoyl-Lysyl-Valyl-Lysine, Pal-Lys-Val-Lys-OH) is also called "tripeptide" or "collagen peptideCOLL-O2 ", the most widely used cosmetic peptide. Palmitoyl tripeptide-5 belongs to the signal peptide class and can promote the synthesis of collagen (I type, II types, and IV type) and the production of extracellular matrix protein by increasing the activity of stromal cells to make the skin looks young and elastic. Collagen can be added to cosmetics to help skin supplement collagen, improve facial elasticity and remarkably reduce facial wrinkles. Meanwhile, the skin care product has the characteristics of enhancing cell activity, increasing the skin’s water content, enhancing the skin luster, and improving the skin color.

In the prior art, more research reports about applying palmitoyl tripeptide-5 exist. As a result of research on the whitening efficacy and action mechanism of palmitoyl tripeptide-5 in the literature [ daily chemical industry, 2018,48(3),166-171], the palmitoyl tripeptide-5 can inhibit the generation of melanin in melanocytes by inhibiting tyrosinase activity and reducing mRNA levels of microphthalmia-associated transcription factor (MITF) and tyrosinase and can be applied to the field of cosmetics as a whitening additive. Chinese patent publication No. CN108619047A discloses an anti-aging cosmetic formulation and a preparation method, wherein one of the anti-aging components is palmitoyl tripeptide 5. Chinese patent with publication No. CN 107669564A discloses a skin care composition with repairing and regenerating, moisturizing, and delaying senility, wherein palmitoyl tripeptide-5 is one of the main components. Many reports of related research need to be listed here.

However, the literature on preparing palmitoyl tripeptide-5 in the prior art is scarce, and the practice of palmitoyl tripeptide-5 by a solid phase synthesis method is mentioned in U.S. Pat. No. 5, 2007099842, 1, but various protecting groups and deprotecting reagents are required, and the final yield is only 19%. Besides the method, this is the only method for preparing the palmitoyl tripeptide-5 reported at present. (CN201910789414.XA, 2020)

Palmitoyl tripeptide-5 acts on specific skin receptors and stimulates collagen production in our skin cells. It firms our skin and reduces the appearance of wrinkles and fine lines. It makes your skin look healthier and fresh.

Palmitoyl Tripeptide-5 also interact with hyaluronic acid and elastin production system. The combined effect is increased water content, reduced skin wrinkling, and enhanced skin firmness.

Additionally, it supports the healthy functioning of the skin cells and helps remove toxins.

Although a relative discovery, Palmitoyl Tripeptide-5 is used in cosmetic formulations that aim to provide anti-aging benefits such as reducing fine lines and achieving smooth skin, especially for sensitive skin.

In-vitro studies have also shown that Palmitoyl Tripeptide-5 can prevent collagen breakdown by avoiding the degradation pathway of Type 1 and Type 3 collagen in the skin. The studies also indicate that this synthetic peptide can boost collagen synthesis.

New products are also being developed using Palmitoyl Tripeptide-5 and other raw ingredients to help reduce redness in Type 1 rosacea. The active complex inhibits stimulating inflammatory proteins known as cytokines in the human body.

• What are palmitoyl Tripeptide-5 and glycerin and aqua?

A. Palmitoyl Tripeptide-5 (and) Glycerin (and) Aqua. SYN® -COLL by DSM acts as an anti-aging, anti-wrinkle, and rejuvenating agent. It is a preservative-free, patented, synthetic tri-peptide with a unique sequence that imitates the human body's mechanism to produce collagen via TGF-β.

• What does palmitoyl tripeptide 5 do for the skin?

A. Palmitoyl tripeptide-5 acts on specific skin receptors and stimulates collagen production in our skin cells. It firms our skin and reduces the appearance of wrinkles and fine lines. It makes your skin look healthier and fresh.

• What do Tripeptides do for your skin?

A. Tripeptides are most commonly used for improving the look of aging signs in the skin, particularly on delicate areas such as the neck. Regular use allows fine lines and wrinkles to appear smoother and improve elasticity.

• Do peptides make your skin glow?

A.Topical peptides send signals to your skin cells to generate more collagen and elastin - vital ingredients for hydrated, youthful-looking skin. To prevent moisture loss while locking in hydration, elastin is an essential protein that works with collagen to deliver that timeless, coveted, youthful glow.

• Is it better to use peptides at night?

A. Often, you can use it: Polypeptides should be applied during morning and nighttime skincare routines for maximum effectiveness. Getting a facial peel before applying peptide products may help peptides penetrate the skin more deeply.

• Do peptides lift skin?

A. These peptides signal your skin to enter repair mode and produce more collagen and elastin—two proteins responsible for keeping skin smooth and firm.” When your skin has more collagen elastin, you'll see fewer fine lines and wrinkles, more petite-looking pores, and a more lifted and contoured appearance.

• How long do peptides take to work on the skin?

A. 2 - 3 weeks 

Introducing peptides into topical skincare helps to provide the building blocks for maintaining structural proteins like collagen in the skin. Consistent use of peptides can start showing noticeable results within 2 - 3 weeks.

• Can I use peptides every day?

A. It's safe to use your peptide serum twice a day, but once a day is usually enough. This depends on how often you use it with the skin conditions you're trying to address, your regimen, and how quickly you want to see the final results. Often, daily use can help you see results faster in 3 months.

• What are the adverse effects of peptides?

A. The peptide hormone abuse can cause motor paralysis, skeletal muscle damage and loss, diabetes mellitus, hypothyroidism, arterial hypertension, sweating, headaches, and vomiting and enhances the risk for atherosclerosis, thrombosis, osteoporosis, and cancer.

• When should I apply peptides to my face?

A. The key to using peptide serum is to apply it to freshly washed skin. So, after you've used your cleanser. After you've washed and exfoliated your face and neck area, apply your toner, then the peptide serum according to the instructions on the label. Next, you should apply a moisturizer.

• Are peptides or vitamin C better for the skin?

A. While peptides do not address acne or rosacea directly, they can assist with the redness and inflammation from acne scarring. In summary, vitamin C is an incredibly effective preventative because of its unique ability to scavenge free radicals.

• Are peptides better than retinol?

A. Retinol improves collagen synthesis in the skin, but often at the expense of skin dryness, inflammation, and sun sensitivity. Peptides are generally more gentle and moisturizing than retinol and, therefore a better choice for those with a more sensitive skin type.

• Do collagen peptides make you look younger?

A. Collagen is an essential protein that keeps your tissues and bones together. Specifically for your skin, collagen helps give your skin structure and elasticity, or that famous “bounce.” So, in theory, boosting your skin's collagen levels — or preventing its loss — would help you look younger.

• How long does it take for collagen peptides to start working?

A. Most people will generally see a benefit after taking 10 grams of collagen peptides daily for 4-12 weeks. However, keep in mind that this will vary from person to person. Most importantly, ensure to eat a healthy, balanced diet rich in whole foods to reap the most benefit from your collagen supplement.

• Do peptides improve skin texture?

A. PEPTIDES HELP EVEN OUT SKIN TONE AND TEXTURE. When collagen production increases, skin becomes plumper, more transparent and healthier—and skin texture and tone become evened out.

• Do peptides remove dark spots?

A. This helps reduce the appearance of dark spots or hyperpigmentation, including age spots, acne scars, and other types of skin discoloration. ¹ If you have an uneven or dull complexion, copper peptides can help you get closer to a brighter and more even skin tone.

• At what age should you use peptides?

A. When and how to use skincare ingredients

• Can I use peptides every night?

A. Generally, however, polypeptides are safe to use twice daily. It's also recommended that you opt for a peptide product that can be left on the skin, such as a cream or serum.

• What are the side effects of peptides for skin care?

A. Peptides for Skincare Side Effects

These side effects can include skin sensitivity, rash, and itching. To avoid this, patch-test your skincare before trying a new product to ensure your skin won't react to a Peptide-infused product.

• Do peptides work?

A. Peptides are sold in dietary supplements, including pills or protein shakes. They claim to help you build muscle, boost weight and fat loss, and help with muscle recovery. But there's little direct evidence to back up most of these statements. And it's unclear how well your body can absorb peptides from supplements.

• Can you put moisturizer over peptides?

A. Peptides work excellently alongside other ingredients, like hyaluronic acids and vitamin C. Additionally, you may consider pairing harsh skin products, such as retinol, with a peptide moisturizer to build the skin's barrier back up. Therefore, there's no need to throw away your expansive skincare collection!

• Do peptides cause sagging skin?

A. Peptides are key in making elastin fibers, a type of protein needed for enhancing skin elasticity and firmness. Regular use of peptides can make the skin look firmer and reduces sagging skin.

•  What are better peptides or hyaluronic acid?

A. Copper-based products are available in lotions, creams, serums, and masks. Copper peptide is superior to hyaluronic acid as it provides multiple benefits to your skin, but hyaluronic aits a moisturizer.

• Do peptides have side effects?

A. Reported side effects of peptides and hormones to include Water retention. Numbness of the hands and feet. Increased tiredness.

• Do peptides help pigmentation?

A. Reduce pigmentation and age spots
By blocking this pathway, the peptide makes it much harder for melanogenesis to start. Doing so helps reduce the development of pigmentation, uneven skin tone, and dark spots.

• What not to mix with peptides?

A. When it comes to layering peptides with other effective skin ingredients, there are some popular ones that should be avoided.

• Retinol.
• Tretinoin.
• Vitamin C.
• AHAs/ BHAs such as glycolic acid and salicylic acid.

• How do peptides affect the brain?

A. This peptide is a memory booster that aides in optimal learning. It increases Brain-derived neurotrophic factor (BDNF), which can help with depressive emotions and eases anxiety. This is accomplished by altering the expression of specific genes and changing the immune system’s response.

• Why are peptides good for the skin?

A. Peptides, however, are amino acids that can penetrate the skin barrier and aid in your body's natural collagen production from the inside out. Your body requires peptides to produce collagen and elastin, keeping skin firm and youthful.

• What is palmitoyl tripeptide-5 made of?

A. What is Palmitoyl Tripeptide-5? Palmitoyl Tripeptide-5 is a synthetic peptide formed by linking the amino acids Lysine-Valine-Lysine together. Peptides are chains of amino acids linked together, and amino acids are building blocks of protein.

• Is palmitoyl tripeptide-5 palm oil?

A. Palmitoyl Tripeptide-5 is made from sustainable palm oil and amino acids and is suitable for use by vegetarians and vegans – reassuring for those wishing to avoid products using collagen from animal sources.

• Is palmitoyl Tripeptide-5 safe?

A. Palmitoyl Tripeptide-5 is a new ingredient, and there are few researchers on it. But according to a skincare specialist, Palmitoyl Tripeptide-5 is safe to use on any skin. It can't react to your skin. There are no reported issues of any toxicity, allergy, sensitivity, and hormone disruption.

• What is the difference between tripeptide and peptide?

A. A peptide is the name assigned to short polymers of amino acids. They are classified by the number of amino acid units in the chain, called amino acid residues. Tripeptides have three amino acid residues, while tetrapeptides have four.

• Is palmitoyl tripeptide-5 natural?

A. Palmitoyl tripeptide is a new peptide that has recently been discovered. These compounds occur naturally in our body, but due to their popularity as an anti-aging effect; many skincare companies are creating them synthetically in the lab to provide greater control over the effects.

• Is palmitoyl tripeptide-5 palm oil?

A. Palmitoyl Tripeptide-5 is made from sustainable palm oil and amino acids and is suitable for use by vegetarians and vegans – reassuring for those wishing to avoid products using collagen from animal sources.

• What is palmitoyl made from?

A. Palmitoyl tetrapeptide-7 is a synthetic peptide composed of glutamine, glycine, arginine, and proline amino acids.

• What is tripeptide called?

A. The simplest tripeptide is glycine. In scientific investigations, the dominant tripeptide is glutathione (γ-L-Glutamyl-L-cysteinyl glycine), which serves many roles in many life forms.

• Who discovered peptides?

A. Emil Fischer is considered to be the founding father of the field of peptide chemistry and the originator of the term peptide. At the beginning of the 20th century, Fischer clearly envisioned when a protein would be synthesized.

• DSM. (n.d.). SYN®-COLL. Retrieved from https://www.dsm.com/personal-care/en_US/products/skin-bioactives/syn-coll.html
• DSM. (n.d.). Scroll. Retrieved from https://www.knowde.com/stores/dsm/products/dsm-syn-coll