• Follicusan™ DP is an effective and well-tolerated bioactive complex. (Clr-berlin, 2025)

• reduces hair loss and supports natural growth. (Clr-berlin, 2025)

• This bioactive complex stimulates cellular renewal within the scalp and hair follicles, promoting a healthier scalp environment and mitigating premature or excessive hair shedding. (Clr-berlin, 2025)

• It contains a synergistic combination of bioactive signaling proteins and ethyl panthenol, inositol, acetylcysteine, and acetyl methionine, all delivered in a balanced aqueous-alcoholic medium. (Clr-berlin, 2025)

• Signaling proteins are flexible molecules that transmit signals between cells, helping regulate growth, differentiation, and immune responses.

• Follicusan DP also supports scalp health by energizing the cells and reducing problems like too much oil production, which can lead to dandruff. (Clr-berlin, 2025)

Follicusan™ DP is an effective and well-tolerated bioactive complex that reduces hair loss and supports natural growth. It features a synergistic blend of biologically active signaling proteins and ethyl panthenol, inositol, acetylcysteine, and acetyl methionine—delivered in a carefully formulated aqueous-alcoholic base.

This active complex revitalizes scalp cells, including those within the hair follicles, enhancing scalp vitality and counteracting premature or excessive hair loss. With its proven efficacy and no side effects, Follicusan DP offers a science-backed solution for healthier, fuller-looking hair. (Clr-berlin, 2025)

The dermal papilla (DP) is a special group of cells at the base of the hair follicle. It acts as a chemical and physical support system for the stem cells that grow new hair. The DP controls each hair's size, shape, color, and growth cycle.

Studies show that the number of DP cells is very important; hair can become thinner or fall out if it gets too low. The DP also stays connected to the growing part of the hair follicle, even as the follicle goes through different stages: growth (anagen), shrinkage (catagen), rest (telogen), and regrowth.

Hair thinning and loss often happen because the number of dermal papilla (DP) cells in each hair follicle decreases. In androgenetic alopecia (male pattern baldness), this may be due to a problem that starts in the DP itself. The pattern of baldness may be linked to differences in how the scalp develops in different regions of the head.

The dermal papilla (DP) is made of special mesenchymal cells inside hair follicles that are key for controlling hair growth. It’s essential to keep dermal papilla cells (DPCs) and dermal sheath cells healthy and able to grow hair. (Taghiabadi, Nilforoushzadeh,and Aghdami, 2020)

Certain substances can be applied topically to influence dermal papilla cells (DPCs), which play a crucial role in hair follicle growth and cycling. (Tong, Kim, and Park, 2015)

Dermal Papilla & Follicusan™ DP:

Follicusan™ DP stimulates the functionality of the dermal papilla cells at the base of the hair follicles, thus counteracting premature hair loss. It increases the number of anagen hair follicles (growth stage) and decreases that of telogen hair follicles (resting stage). Hair density and cumulative hair thickness are increased.

Follicusan™ DP contains biologically active signaling proteins, ethyl panthenol (provitamin B5), inositol, acetylcysteine, and acetyl methionine in a water-ethanol medium. (Clr-berlin, 2025)

What are biologically Active signaling Proteins?  

Biologically active signaling proteins are highly dynamic molecules that transmit information within and between cells. These proteins are uniquely flexible in structure and function, enabling them to bind with various molecular partners and integrate diverse cellular cues. Their primary role is to regulate critical biological processes, such as cell growth, differentiation, immune response, and cell degeneration, by relaying signals through intracellular pathways. (Radfar et al., 2015)

Contents of Follicusan™ DP and their contribution to Hair growth: 

Follicusan™ DP is an innovative active complex developed by the German company CLR, designed to support hair vitality and growth. This unique formulation combines bioactive signaling molecules derived from milk with DL-panthenol (provitamin B5), inositol, and sulfur-rich amino acid derivatives such as N-acetylcysteine and N-acetyl-Methionine. Together, these components work synergistically to strengthen the hair, reduce hair loss, and reactivate dormant hair follicles. By stimulating the transition from the resting telogen phase to the active anagen phase, Follicusan promotes healthier, denser, and more resilient hair growth. (Beurre, 2025). 

• Milk Protein (Lactis Proteinum): 

Lactis Proteinum or milk protein, can contribute to hair growth and overall hair health by providing essential amino acids and promoting hair elasticity and strength. It also helps retain moisture, making hair smoother and more manageable.

1. A general term referring to all the proteins in milk.

2. Milk contains a variety of proteins with diverse functions.

3. Lactis Proteinum has been used in skincare for its nourishing and conditioning properties, promoting skin regeneration and hydration.

4. Lactis Proteinum is soluble and versatile. It possesses excellent anti-irritant and protective properties and gives an optimal balance of nutrients and moisture to hair.

Some studies suggest that lactoferrin, a protein found in milk, may stimulate the proliferation of dermal papilla cells, which are essential for hair follicle growth. (Hsiu-Chin Huang, 2019)

Research indicates that milk protein may influence the Wnt signaling pathway, which is involved in hair follicle development and growth. (Huang, Lin, and Huang, 2019)

• Panthenyl Ethyl Ether: 

It is a water-soluble form of vitamin B5 often used in hair, skin, and nail care products. It turns into pantothenic acid in the body, which helps make coenzyme A, a compound important for healthy cell function. Studies have shown that PEE can help boost the growth of hair follicle cells, which may support healthier, faster hair growth. (Hu et al., 2022) 

• Inositol: 

Inositol is a natural sugar in many foods and has nine different forms. The two most common and beneficial forms are myo-inositol and D-chiro-inositol. These forms are known to help with metabolic and hormonal issues. 

They are found in foods like fruits and beans and are made by the body. They help cells respond to hormones like insulin. When this process doesn’t work well, it can cause insulin resistance, which is linked to high androgen levels—a significant cause of hair loss (alopecia) and excess facial hair (hirsutism) in women. Inositol may help by improving insulin sensitivity and reducing these symptoms. 

Inositol is also used in cosmetic and hair care products because it may help with hair loss, especially when the cause is related to hormonal imbalances. By supporting healthy hormone levels and improving how the body uses insulin, inositol can contribute to stronger, healthier hair growth in some people. (King, 2025)

• Acetyl Cysteine: 

Acetyl cysteine is an organic compound that conforms to the formula. Acetyl cysteine is the amide formed from acetic acid chloride and cysteine. (Burnett et al., 2017)

It is also a thiol compound, meaning it contains sulfur, which helps it fight harmful substances and protect cells. Since it is derived from L-cysteine, a natural amino acid in the body, it plays a vital role in keeping our cells healthy and protecting against damage. (Adil, Amin and Mohtashim, 2018)

Acetylcysteine is a substance that helps protect the body from damage caused by stress, infections, and harmful chemicals. It works as an antioxidant, fighting harmful molecules called free radicals. Because of this, NAC is used in many areas of medicine, including skin care. Scientists are studying how it can help with different skin problems by reducing inflammation and protecting skin cells from damage. (Adil, Amin and Mohtashim, 2018)

Acetylcysteine is a powerful antioxidant that helps protect the hair and scalp. It reduces harmful molecules called free radicals that can damage hair follicles and speed up hair loss. Acetylcysteine also helps slow down the aging of special cells (dermal papilla cells) that are key for hair growth.

Some animal studies show that Acetylcysteine may protect against hair loss caused by chemotherapy. It can also reduce inflammation in the scalp by calming specific pathways linked to skin irritation and damage.

In short, Acetylcysteine helps protect hair roots, supports healthy growth, and keeps the scalp calm and balanced. (Adil, Amin and Mohtashim, 2018)

• Acetyl Methionine:

It is a modified form of the amino acid methionine, in which an acetyl group is attached to the nitrogen atom of methionine. This simple chemical change makes the molecule more stable and often easier for the body to absorb and use. 

Like methionine, it plays an important role in protein formation, especially keratin, the main structural protein in hair. The added acetyl group can also enhance its effectiveness in topical products or supplements, potentially improving its ability to support hair growth, repair, and overall scalp health. (Pubchem, 2025) 

Acetyl methionine is included in some hair care products because it can stimulate hair follicles and support hair growth by acting on dermal papilla cells, the key regulators at the base of each hair follicle. It may help improve scalp condition by addressing issues like seborrhea (a flaky, itchy scalp), unclogging follicles, and creating a healthier environment for hair growth. (Clr-berlin, 2025)

The Science Behind Mode of Action: How Follicusan™ DP Works 

Follicusan™ DP is an ingredient that improves the function of cells in the scalp and hair follicles, which can help prevent early hair loss. 

In a study where people used a gel with 5% Follicusan™ DP for three months, it helped balance the hair growth cycle. More hair follicles entered the active growth phase (anagen), and fewer were stuck in the resting phase (telogen), which is a good sign for hair regrowth. Follicusan™ DP also supports scalp health by energizing the cells and reducing problems like too much oil production, which can lead to dandruff. (Clr-berlin, 2025) 

Application: 

Follicusan™ DP is designed for the preventative care of the scalp and hair. It can be used in aqueous and aqueous-alcoholic hair care formulas. (Clr-berlin, 2025)  

• Adil, M., Amin, S.S. and Mohtashim, M., 2018. N-acetylcysteine in dermatology. Indian Journal of Dermatology, Venereology and Leprology, 84, p.652. Click Here
• Beurre., 2025. FOLLICUSAN DP- Description. Click Here
• Burnett, C.L., Heldreth, B., Bergfeld, W.F., Belsito, D.V., Hill, R.A., Klaassen, C.D., Liebler, D.C., Marks Jr, J.G., Shank, R.C., Slaga, T.J. and Snyder, P.W., 2017. Safety assessment of amino acid alkyl amides as used in cosmetics. International journal of toxicology, 36(1_suppl), pp.17S-56S. Click Here
• ClevelandClinic., 2022. Hair Follicle. Click Here
• Clr-berlin., 2025. Follicusan™ DP. Clr-Berlin. Click Here
• Hu, L., Kimura, S., Haga, M., Kashiwagi, S., Takagi, K., Shimizu, T., Ishii, T. and Ohyama, M., 2022. Vitamins and their derivatives synergistically promote hair shaft elongation ex vivo via PlGF/VEGFR-1 signalling activation. Journal of Dermatological Science, 108(1), pp.2-11. 
• Huang, H.C., Lin, H. and Huang, M.C., 2019. Lactoferrin promotes hair growth in mice and increases dermal papilla cell proliferation through Erk/Akt and Wnt signaling pathways. Archives of dermatological research, 311, pp.411-420. Click Here
• King, S., 2025. Inositol: A Sugar That Supports Hair Growth? | Clinical Study Analysis. PerfectHairHealth. Click Here
• Pubchem., 2025. N-Acetylmethionine. Click Here
• Radfar, L., Ahmadabadi, R.E., Masood, F. and Scofield, R.H., 2015. Biological therapy and dentistry: a review paper. Oral surgery, oral medicine, oral pathology and oral radiology, 120(5), pp.594-601. Click Here
• Taghiabadi, E., Nilforoushzadeh, M.A. and Aghdami, N., 2020. Maintaining hair inductivity in human dermal papilla cells: a review of effective methods. Skin pharmacology and physiology, 33(5), pp.280-292. Click Here
• Tong, T., Kim, N. and Park, T., 2015. Topical application of oleuropein induces anagen hair growth in telogen mouse skin. PloS one, 10(6), p.e0129578. Click Here